Chronic Kidney Disease concludes the conditions that damage our kidneys and decrease their ability to keep our healthy. With many different causes, Chronic Kidney Disease can causes piling up of wastes in our blood and then make us feel sick.

Firstly, Hypertension is one of the leading causes of Chronic Kidney Disease. As blood pressure against the walls of blood vessels, large amount of protein may leak out of blood vessels. Long-term leakage of protein will cause damage to the filtration membrane which is composed of different function cells, leading to the vicious circle. Great destroy of renal damage is difficult to reverse and will give rise to beforehand failure of kidneys. This is the reason why is hematuria not as terrible as proteinuria for people with Chronic Kidney Disease.

Secondly, another leading cause of Chronic Kidney Disease is Diabetes. Diabetes happens when blood sugar is too high. Long time increased blood sugar not only causes damages to kidneys, but also causes damages to our many other organs such as heart, nerves, blood vessels and eyes. As the leading causes of Chronic Kidney Disease, Hypertension and Diabetes are responsible for up to two-thirds of the cases.

Thirdly, being divided into primary glomerulonephritis and secondary glomerulonephritis, glomerulonephritis is another major cause of Chronic Kidney Disease. It mainly refers to the glomerular damage and the chief manifestations of it are proteinuria, hematuria, swelling and high blood pressure.

Fourthly, inherited disease such as Polycystic Kidney Disease which means there are many cysts on the kidneys can cause Chronic Kidney Disease as well. Enlarged cysts will oppress the surrounding renal tissues, leading to the ability of some of renal intrinsic cells and as a result, glomerular filtration rate decreases. Glomerular filtration rate is one of the major indexes indicating Chronic Kidney Disease and decreased of it usually indicates the poor renal function.

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